Comparison of Fully Quantitative and Semi-Quantitative Measure of Womens Myocardial Perfusion Reserve for Detection of Microvascular Coronary Dysfunction

David Chen¹, Behzad Sharif¹, Afsaneh Haftbaradaran¹, Melody Zaya¹, Chrisandra Shufelt¹, Puja Mehta¹, Daniel S. Berman¹, Louis EJ Thomson¹, Debiao Li¹, Noel Bairey Merz¹

Myocardial perfusion reserve (MPR) acquired using first-pass cardiac MRI is a measure of the severity of microvascular coronary dysfunction (MCD) in subjects with signs and symptoms of ischemia but no obstructive coronary artery disease (CAD). Semi-quantitative measures (upslopes) have been used to analyze MPR data in the previous work. In this work, we propose using a fully quantitative myocardial blood flow (MBF) analysis to evaluate whether MPR is different between subjects with MCD and normal controls. MPR measured by quantitative MBF analysis provides better detection of MCD than that using semi-quantitative upslopes.