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Abstract #4537

High Resolution Three Dimensional Intracranial Arterial Wall Imaging at 3T Using SNR-Optimized T1 Weighted SPACE

Lei Zhang1, 2, Qing Zhai3, Na Zhang1, 2, XiaoXin Tong3, Xin Liu1, 2, Yiu-cho Chung1, 2

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institution of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; 2Shenzhen Key Laboratory for MRI, Shenzhen, Guangdong, China; 3Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

Intracranial atherosclerosis is a major cause of ischemic stroke. T1w-SPACE can be used to image vessel wall of intracranial arteries. However, scan time, spatial coverage and contrast compete with each other in this technique. Here, Bloch equation simulation was performed to understand the relationships among these key imaging parameters. Results were verified by volunteer study. In patients, a shorter than optimal TR was need to increase anatomical coverage. Intracranial plaques were successfully identified by pre- and post-contrast T1w-SPACE. This technique may be a clinically useful tool for screening intracranial arterial disease in patients with high risk of ischemic stroke.