Abstract #4569

Arrhythmia Insensitive Rapid Cardiac T1 Mapping Pulse Sequence: in vivo Study

Michelle Fitts¹,², Elodie Breton³, Eugene G. Kholmovski,²⁴, Derek J. Dosdall²,⁵, Sathya Vijayakumar,²⁴, Kyung P. Hong¹,², Ravi Ranjan²,⁵, Nassir F. Marrouche²,⁵, Leon Axel⁶, Daniel Kim²,⁴

¹Bioengineering, University of Utah, Salt Lake City, UT, United States; ²CARMA Center, University of Utah, Salt Lake City, UT, United States; ³ICube, Strasbourg University, Strasbourg, Alsance, France; ⁴UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, United States; ⁵Internal Medicine, University of Utah, Salt Lake City, UT, United States; ⁶Department of Radiology, New York University, New York, United States

We propose an arrhythmia-insensitive, rapid (AIR) cardiac T1 mapping pulse sequence based on saturation recovery, which is insensitive to heart rate and rhythm conditions, for quantification of diffuse fibrosis. We compared its performance against the conventional cardiac T1 mapping inversion recovery based method, MOLLI, which is sensitive to heart rate and rhythm conditions and requires a long breath-hold duration. In vivo studies demonstrated that T1 measurements made by MOLLI and AIR were strongly correlated, but in poor agreement. Our AIR pulse sequence may be clinically useful for assessment of diffuse myocardial fibrosis in patients.