Abstract #0015
Mapping higher-order brain function and resting-state networks with diffuse optical tomography
Adam T Eggebrecht 1 , Silvina L Ferradal 2 , Amy Robichaux-Viehoever 1 , Mahlega Hassanpour 3 , Hamid Dehghani 4 , Abraham Z Snyder 5 , Tamara Hershey 6 , and Joseph P Culver 1,2
1
Radiology, Washington University School of
Medicine, St. Louis, MO, United States,
2
Biomedical
Engineering, Washington University School of Medicine,
MO, United States,
3
Physics,
Washington University School of Medicine, MO, United
States,
4
School
of Computer Science, University of Birmingham, United
Kingdom,
5
Neurology,
Washington University School of Medicine, MO, United
States,
6
Psychiatry,
Washington University School of Medicine, MO, United
States
Mapping distributed brain function has transformed our
understanding of brain function. Brain function
traditionally, has been studied with positron emission
tomography (PET) and with functional magnetic resonance
imaging (fMRI). However, PET uses ionizing radiation,
which is not permitted as an experimental procedure in
children. fMRI involves exposure to strong magnetic
fields and induced electric fields, which is
contraindicated in patients with implanted electronic
devices (e.g., deep brain stimulators, pacemakers,
cochlear implants). I present herein a large
field-of-view high-density diffuse optical tomography
(HD-DOT) system with anatomical modeling approaches that
collectively provide new imaging capabilities and enable
novel milestones for optical neuroimaging.
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