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Abstract #0023

MRI Demonstrates a Decrease in Myocardial Infarct Healing and Increase in Compensatory Ventricular Hypertrophy Following Mechanical Microvascular Obstruction

Hisham Z. Bajwa 1 , Lois Do 1 , Mohammed Suhail 1 , Steve W. Hetts 1 , Mark W. Wilson 1 , and Maythem Saeed 1

1 Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States

Our study was aimed at providing direct evidence that mechanical obstruction of microvessels in the coronary vasculature inhibits myocardial infarct resorption and enhances LV remodeling using MRI and then confirming these findings with histopathology. We found that persistent microvascular obstruction after 3 days was larger on average and more frequently found in animals that underwent LAD occlusion/microemboli delivery/reperfusion than animals that were only subjected to occlusion/reperfusion. The greater microvascular obstruction in the former was associated with less infarct resorption, a greater degree of increase in LV mass and more pronounced decline in LV ejection fraction.

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