Abstract #0060
Diffusion tensor MRI and tractography of the sacral plexus in children with spina bifida
Wieke Haakma 1,2 , Pieter Dik 3 , Bennie ten Haken 4 , Martijn Froeling 1 , Rutger Jan Nievelstein 1 , Jeroen Hendrikse 1 , Inge Cuppen 5 , Tom de Jong 3 , and Alexander Leemans 6
1
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
2
Department
of Forensic Sciences and Comparative Medicine Lab,
Aarhus University, Aarhus, Central Denmark, Denmark,
3
Pediatric
Urology, University Medical Center Utrecht, Utrecht,
Netherlands,
4
Institute
for Biomedical Technology & Technical Medicine,
University of Twente, enschede, Overijssel, Netherlands,
5
Pediatric
Neurology, University Medical Center Utrecht, Utrecht,
Netherlands,
6
Image
Science Institute, University Medical Center Utrecht,
Utrecht, Netherlands
It is still largely unknown how neural tube defects in
spina bifida (SB) affect the nerves at the level of the
sacral plexus. Visualizing the sacral plexus in 3D could
improve anatomical understanding regarding neurological
problems. 10 SB patients underwent DTI on a 3 Tesla MRI.
With tractography the microstructural properties of the
nerves were investigated and were compared with 10
healthy controls. The sacral plexus of SB patients
showed asymmetry, disorganization and lower diffusion
values compared to healthy controls. We expect that this
technology can provide a valuable contribution to a
better analysis of these patients in the future.
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