Abstract #0065
Caloric Restriction Impedes Age-related Decline of Neuronal Function and Energy Demand
Ai-Ling Lin 1 , Daniel Coman 2 , Lihong Jiang 2 , Douglas L Rothman 2 , and Fahmeed Hyder 2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States,
2
Magnetic
Resonance Research Center, Yale University, New Haven,
CT, United States
While caloric restriction extends mammalian lifespan,
its effect on neuronal function and energy demand
especially in healthy aging remains largely unknown.
Using
1
H[
13
C]
MRS techniques, we show that healthy aging rats had
significantly lower rates of neuronal energy production
and neurotransmission relative to their younger
counterparts; however, caloric restriction mitigated the
age-related deceleration of brain physiology. These
results provide a rationale for caloric
restriction-induced sustenance of brain health with
extended lifespan.
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