Abstract #0097
Metabolic confinements in normal and stroked CNS in vivo revealed by localized double-Pulsed-Field-Gradient MRS at 21.1 T
Noam Shemesh 1 , Jens T Rosenberg 2,3 , Jean-Nicolas Dumez 1 , Samuel Colles Grant 2,3 , and Lucio Frydman 1,2
1
Chemical Physics, Weizmann Institute of
Science, Rehovot, Israel,
2
National
High Magnetic Field Laboratory, The Florida State
University, Tallahassee, FL, United States,
3
Chemical
& Biomedical Engineering, The Florida State University,
Tallahassee, FL, United States
Microstructural characterizations of the Central Nervous
System are limited by waters non-specificity. Whereas
diffusion Magnetic Resonance Spectroscopy (MRS) methods
utilize a spectral dimension to impart specificity, they
still rely on detection of Apparent Diffusion
Coefficients (ADCs), whose relationship with underlying
microstructural determinants are tenuous. Here, we
combine a recent spectrally-specific Longitudinal
Relaxation Enhancement (LRE) approach with the
double-Pulsed-Field-Gradient (dPFG) approach that
provides unambiguous and clear indications for
restricted diffusion. The ensuing localized dPFG MRS
provides unique signatures for metabolic confinements,
which are shown to vary in stroked rats. These unique
measurements provide a glimpse into the nature of ADC
variations in stroke.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
