Abstract #0103
Resolving Myelin and Axonal Properties within the Same Voxel in Presence of Crossing Fibers by Combining Inversion Recovery and Diffusion Acquisitions
Silvia De Santis 1,2 , Daniel Barazany 1,2 , Derek K Jones 1 , and Yaniv Assaf 2
1
School of Psychology, CUBRIC, Cardiff, UK,
United Kingdom,
2
Department
of Neurobiology, Tel Aviv University, Tel Aviv, Israel,
Israel
The purpose of this work is to develop a new
acquisition&analysis strategy, by combining inversion
recovery with conventional diffusion tensor imaging, and
by acquiring CHARMED protocol to calculate fiber
orientations and volume fractions. For each fiber
population present within a voxel, we extract a specific
longitudinal relaxation time T1 by exploiting the
orientational dependence of the diffusion-weighted
signal that has been previously inversion-prepared. As
the relaxation time T1 has been established as a solid
proxy for myelination, this method effectively succeeds,
for the first time, to resolve both axonal and myelin
properties in presence of crossing fibers.
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