Abstract #0106
Oscillating Gradient Spin-Echo (OGSE) DTI Yields Mechanistic Insights in Human Stroke
Corey A Baron 1 , Mahesh P Kate 2 , Laura C Gioia 2 , Ken Butcher 2 , Derek Emery 3 , Matthew D Budde 4 , and Christian Beaulieu 1
1
Biomedical Engineering, University of
Alberta, Edmonton, Alberta, Canada,
2
Neurology,
University of Alberta, Alberta, Canada,
3
Radiology,
University of Alberta, Alberta, Canada,
4
Department
of Neurosurgery, Medical College of Wisconsin,
Wisconsin, United States
The mechanisms behind the marked reduction of mean
diffusivity (MD) of water using standard pulsed gradient
spin echo (PGSE) diffusion MRI after acute ischemic
stroke are still not well understood. Here, oscillating
gradient spin-echo (OGSE) diffusion MRI that enables
short diffusion times of 4 ms demonstrated only a 14%
drop of MD within human acute ischemic stroke lesions,
as opposed to a 44% drop using PGSE with a much longer
40 ms diffusion time. This agreed well with Monte Carlo
simulations of axon beading at the two diffusion times,
supporting its role for MD reductions during stroke.
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