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Abstract #0106

Oscillating Gradient Spin-Echo (OGSE) DTI Yields Mechanistic Insights in Human Stroke

Corey A Baron 1 , Mahesh P Kate 2 , Laura C Gioia 2 , Ken Butcher 2 , Derek Emery 3 , Matthew D Budde 4 , and Christian Beaulieu 1

1 Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, 2 Neurology, University of Alberta, Alberta, Canada, 3 Radiology, University of Alberta, Alberta, Canada, 4 Department of Neurosurgery, Medical College of Wisconsin, Wisconsin, United States

The mechanisms behind the marked reduction of mean diffusivity (MD) of water using standard pulsed gradient spin echo (PGSE) diffusion MRI after acute ischemic stroke are still not well understood. Here, oscillating gradient spin-echo (OGSE) diffusion MRI that enables short diffusion times of 4 ms demonstrated only a 14% drop of MD within human acute ischemic stroke lesions, as opposed to a 44% drop using PGSE with a much longer 40 ms diffusion time. This agreed well with Monte Carlo simulations of axon beading at the two diffusion times, supporting its role for MD reductions during stroke.

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