Abstract #0125
Structural brain changes after rotarod training in mice
Jan Scholz 1 , Yosuke Niibori 2 , Paul Frankland 2,3 , and Jason Lerch 1,4
1
Mouse Imaging Centre, Hospital for Sick
Children, Toronto, ON, Canada,
2
Program
in Neurosciences and Mental Health, Hospital for Sick
Children, Toronto, ON, Canada,
3
Department
of Psychology & Physiology, University of Toronto,
Toronto, ON, Canada,
4
Medical
Biophysics, University of Toronto, Toronto, ON, Canada
Here we investigate how rotarod training affects brain
volume and microstrucure using ex-vivo MRI in mice. The
rotarod is a standard test that taxes motor coordination
and balance. Volume of motor and balance-related regions
increases after rotarod training. Volume of the motor
cortex is positively correlated with rotarod performace.
Diffusion imaging indicates that trained mice have
higher FA in the hippocampus. Time spent on the rotarod
is associated with higher FA in the hippocampus and
lower FA in V1. By using complementary measures of
microstructure and volume this study reveals the
substantial structural reorganization of the adult mouse
brain following a brief period of motor training.
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