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Abstract #0141

In-vivo evaluation of hepatic function using dynamic Gd-EOB-DTPA enhanced MRI with a dual-input one output two-compartment pharmacokinetics model

Jia Ning 1 , Sheng Xie 2 , Lei Wang 2 , Hua Guo 1 , Xihai Zhao 1 , Chun Yuan 1,3 , and Huijun Chen 1

1 Center for Biomedical Imaging Research & Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2 Department of Radiology, China-Japan Friendship Hospital, Beijing, China, 3 Department of radiology, University of Washington, Seattle, WA, United States

Liver function is an important and sensitive indicator for liver damage. In this study, we proposed a new hemodynamic model to better describe the behavior of the Gd-EOB-DTPA by adding a directly measured contrast excretion term from hepatic vein. Validations with serum liver functional parameters were carried out for the proposed model and original model. Model parameters Ki is found significantly correlated with the concentration of preALB and ALB in serum. The proposed dual-input one output two-compartment pharmacokinetics model for dynamic Gd-EOB-DTPA enhanced liver MRI is capable of localized liver function evaluation in-vivo.fibrosis can envolve to cirrhosis and finally end up with hepatic carcinoma. Various studies have shown that fibrosis of level 1 and level 2 can be reversible [2], early diagnosis of liver fibrosis is critical for treatment and recovery. Dynamic contrast enhanced MR imaging is one of the most powerful protocols to evaluate the condition of liver. Gd-EOB-DTPA is a new type of hepatocyte specific contrast agent [3] for liver function evaluation. It has the advantages of specific binding with hepatocytes, and excretion through the hepatic vein, kidney and biliary. According to the properties of this contrast agent, we propose a new hemodynamics model to describe the perfusion of the liver. It is supposed that the parameters of the model can give an instruction of hepatic function and provide useful information for diagnosis of liver fibrosis.

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