Abstract #0149
Sensitivity of Multicomponent Driven Equilibrium Single Observation of T1 and T2 (mcDESPOT) to Magic Angle Effects in Bovine Articular Cartilage at 3.0T
Rajeev Chaudhary 1 , Fang Liu 2 , Nade Sritanyaratana 1 , Jarred M. Kaiser 3 , Samuel A. Hurley 2 , Walter F. Block 1,2 , and Richard X. Kijowski 4
1
Biomedical Engineering, University of
Wisconsin-Madison, Madison, WI, United States,
2
Medical
Physics, University of Wisconsin-Madison, Madison, WI,
United States,
3
Mechanical
Engineering, University of Wisconsin-Madison, Madison,
WI, United States,
4
Radiology,
University of Wisconsin-Madison, Madison, WI, United
States
This study was performed to investigate the influence of
the magic angle effect on multi-component T2 parameters
measured using mcDESPOT. Ex-vivo articular cartilage
specimens were imaged using mcDESPOT at angles of 0,
30, 55, and 60 relative to the main magnetic field.
Percent changes in T2 parameters from 0 to 55 where
there was maximum magic angle effect was 42.9% for
single-component T2, 20.0% for T2 of bulk water loosely
bound to the macromolecular matrix, 40.0% for the T2 of
water tightly bound to proteoglycan, and -4.9% for the
fraction of water tightly bound to proteoglycan.
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