Abstract #0158
Impaired synaptic pruning produces long-range functional connectivity deficits in the mouse brain
Alessandro Gozzi 1 , Yang Zhan 2 , Rosa C Paolicelli 2 , Francesco Sforazzini 1 , Alexei Vyssotski 3 , Angelo Bifone 1 , and Cornelius Gross 2
1
MRI Laboratory, Istituto Italiano di
Tecnologia, Centre for Neuroscience and Cognitive
Sciences, Rovereto, Trento, Italy,
2
Mouse
Biology Unit, European Molecular Biology Laboratory (EMBL),
Monterotondo, Italy, Roma, Italy,
3
Institute
of Neuroinformatics, University of Zrich and Swiss
Federal Institute of Technology (ETH), Zurich, Zurich,
Switzerland
Human fMRI studies have revealed impaired long-range
functional connectivity in neuro-developmental disorders
such as schizophrenia and autism. Deficits in the
postnatal elimination of synapses (i.e. pruning), are
thought to play an etiopathological role in these
conditions. We used resting-state fMRI (rsfMRI) to test
whether impaired synaptic maturation is sufficient to
induce functional connectivity deficits. We found that
Cx3cr1-KO mice, a line characterised by marked deficits
in synaptic pruning, exhibit reduced long-range rsfMRI
and LFP coherence in fronto-hippocampal areas. These
results demonstrate that disruption in synaptic pruning
is sufficient to produce connectional deficits
reminiscent of those observed in human
neurodevelopmental disorders
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