Abstract #0163
Restoration of Interhemispheric Resting-state fMRI Connectivity after Patrial Corpus Callosotomy via Intrahemispheric Reorganization
Iris Y Zhou 1,2 , Mengye Lyu 1,2 , Russell W Chan 1,2 , Y X Liang 3 , Adrian Tsang 1,2 , K F So 3 , and Ed X Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong SAR,
China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong SAR, China,
3
Department
of Anatomy, The University of Hong Kong, Hong Kong SAR,
China
Resting-state fMRI (rsfMRI) has shown potentials in
revealing the functional plasticity after brain injury
and training. Our previous study on a rat model of
corpus callosotomy has demonstrated that disrupted
rsfMRI connectivity can be partially restored atop the
axonal connections as indispensable foundation. In this
study, we further investigated the rsfMRI network
reorganization after complete and partial callosotomy,
aiming to identify the rewiring mechanism and
topological alterations of rsfMRI networks if any. The
results showed the restoration of disrupted
interhemispheric connectivity may stem from the
remodeling of intrahemispheric rsfMRI connectivity
together with the remaining interhemispheric axonal
pathways.
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