Neuroadaptation to Single Traumatic Stressor Revealed by Resting-state fMRI in Awake Rats

Alterations of resting-state functional connectivity (RSFC) have been implicated in a wide range of psychiatric disorders. However, RSFC studies focusing on animal models of psychiatric disorders have been sparse, possibly due to confounding effects of widely used anesthesia in animal imaging. To bridge the gap between basic biomedical and human imaging research, in the present study we utilized the awake animal imaging approach established in our lab to evaluate an animal model of post-traumatic stress disorder. We revealed long-lasting impairment of RSFC within the amygdala-mPFC circuit and heightened anxiety level assessed by behavioral measurement after a single-episode predator odor exposure.

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