Abstract #0165
Neuroadaptation to Single Traumatic Stressor Revealed by Resting-state fMRI in Awake Rats
Zhifeng Liang 1 and Nanyin Zhang 1
1
Department of Biomedical Engineering, The
Pennsylvania State University, University Park, PA,
United States
Alterations of resting-state functional connectivity (RSFC)
have been implicated in a wide range of psychiatric
disorders. However, RSFC studies focusing on animal
models of psychiatric disorders have been sparse,
possibly due to confounding effects of widely used
anesthesia in animal imaging. To bridge the gap between
basic biomedical and human imaging research, in the
present study we utilized the awake animal imaging
approach established in our lab to evaluate an animal
model of post-traumatic stress disorder. We revealed
long-lasting impairment of RSFC within the amygdala-mPFC
circuit and heightened anxiety level assessed by
behavioral measurement after a single-episode predator
odor exposure.
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