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Abstract #0185

Characterization of Late Gadolinium Enhancement Heterogeneity in Hypertrophic Cardiomyopathy using Quantitative Texture Analysis

Rebecca E Thornhill 1,2 , Myra Cocker 3 , Girish Dwivedi 3,4 , Carole Dennie 1,2 , Lyanne Fuller 3 , Alexander Dick 3,4 , Terrence Ruddy 3,4 , and Elena Pena-Fernandez 1,2

1 Medical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada, 2 Radiology, University of Ottawa, Ottawa, Ontario, Canada, 3 University of Ottawa Heart Institute, Ottawa, Ontario, Canada, 4 Medicine, University of Ottawa, Ottawa, Ontario, Canada

Late gadolinium enhanced MRI (LGE) can assess the presence and extent of fibrosis in hypertrophic cardiomyopathy (HCM), which is associated with the development of arrhythmias and sudden cardiac death. One of the challenges is how best to describe LGE patterns in HCM, as enhancement may appear subtle or heterogeneous in distribution. Texture analysis was applied to quantify gray-level heterogeneity metrics in both HCM patients and healthy volunteers. These features were significantly elevated in patients with HCM, even in non-hypertrophic, non-fibrotic segments (ie, normal appearing), compared to healthy volunteers. Thus, textural features show potential for markers of cardiomyopathic changes in HCM.

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