Abstract #0185
Characterization of Late Gadolinium Enhancement Heterogeneity in Hypertrophic Cardiomyopathy using Quantitative Texture Analysis
Rebecca E Thornhill 1,2 , Myra Cocker 3 , Girish Dwivedi 3,4 , Carole Dennie 1,2 , Lyanne Fuller 3 , Alexander Dick 3,4 , Terrence Ruddy 3,4 , and Elena Pena-Fernandez 1,2
1
Medical Imaging, The Ottawa Hospital,
Ottawa, Ontario, Canada,
2
Radiology,
University of Ottawa, Ottawa, Ontario, Canada,
3
University
of Ottawa Heart Institute, Ottawa, Ontario, Canada,
4
Medicine,
University of Ottawa, Ottawa, Ontario, Canada
Late gadolinium enhanced MRI (LGE) can assess the
presence and extent of fibrosis in hypertrophic
cardiomyopathy (HCM), which is associated with the
development of arrhythmias and sudden cardiac death. One
of the challenges is how best to describe LGE patterns
in HCM, as enhancement may appear subtle or
heterogeneous in distribution. Texture analysis was
applied to quantify gray-level heterogeneity metrics in
both HCM patients and healthy volunteers. These features
were significantly elevated in patients with HCM, even
in non-hypertrophic, non-fibrotic segments (ie, normal
appearing), compared to healthy volunteers. Thus,
textural features show potential for markers of
cardiomyopathic changes in HCM.
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