Abstract #0187
Quantification of Diffuse Myocardial Fibrosis and Its Association with Diastolic Dysfunction in Patients with Diastolic Heart Failure Using Cardiovascular Magnetic Resonance
Mao-Yuan Marine Su 1 , Lian-Yu Lin 2 , Chin-Chen Chang 1 , Yao-Hui Elton Tseng 1 , Cho-Kai Wu 2 , Jiunn-Lee Lin 2 , and Wen-Yih Isaac Tseng 1,3
1
Department of Medical Imaging, National
Taiwan University Hospital, Taipei, Taiwan,
2
Department
of Internal Medicine, National Taiwan University
Hospital, Taipei, Taiwan,
3
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taiwan
This study investigated whether the diastolic
dysfunction of left ventricular (LV) was associated with
diffuse myocardial fibrosis in patients with diastolic
heart failure (DHF). Forty patients with DHF, 27
patients with systolic heart failure (SHF) and 22
patients without heart failure (control) were studied
using cardiovascular magnetic resonance. Patients with
SHF and DHF both showed increased diffuse myocardial
fibrosis and decreased diastolic function as compared to
controls. Correlation analysis demonstrated that the
extracellular volume fraction (ECV) was significantly
correlated with systolic and diastolic function in DHF.
There was no significant correlation between ECV and the
other functional indices in SHF and non-HF controls. Our
findings support that increased diffuse myocardial
fibrosis may impair the diastolic function but also
affect the systolic function in patients with DHF.
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