Preliminary Application of in vivo Cardiac Diffusion Weighted MRI at 3T in Chronic Myocardial Infarction Porcine Model
Christopher Nguyen 1,2 , Yibin Xie 1,2 , Zhaoyang Fan 1 , Behzad Sharif 1 , James Dawkins 3 , Eleni Tseliou 3 , Xiaoming Bi 4 , Rohan Dharmakumar 1 , Eduardo Marban 3 , and Debiao Li 1,2
Biomedical Imaging Research Institute,
Cedars-Sinai Medical Center, Los Angeles, CA, United
University of California Los Angeles, Los Angeles, CA,
Institute, Cedars-Sinai Medical Center, Los Angeles, CA,
R&D, Siemens Healthcare, Los Angeles, CA, United States
Using a chronic myocardial infarction (MI) pig model, we
demonstrated that motion compensated cardiac
diffusion-prepared turbo-spin echo was able to reveal
statistically significant increases (~50%) in trace
apparent diffusion coefficient (trADC) in late
gadolinium enhanced (LGE)-defined chronic MI regions.
Because the infarcted region is akinetic, bulk motion
corruption would have resulted in a decrease in trADC,
which is opposite to the expected and reported increase
in trADC. Furthermore, the agreement in trADC-defined MI
location and area with LGE-defined MI regions suggests
that the proposed technique delineated infarct tissue.
This may potentially allow for non-contrast tissue
characterization of chronic MI.
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