Abstract #0196
Relaxometry of Bacterially Derived Organelles: A Novel Class of MRI Contrast Agent for Cell Labeling and Tracking
Kimberly Brewer 1 , Rehan Ali 2 , James A Rioux 1 , Sui Seng Tee 1 , Alexey Bazarov 2 , Suleyman Felek 2 , Caleb Bell 2 , and Brian K Rutt 1
1
Radiology, Molecular Imaging Program,
Stanford University, Stanford, California, United
States,
2
Bell
Biosystems Inc, Palo Alto, California, United States
Bacterial-derived pseudo-organelles, Magnelles, were
recently developed as a novel, magnetite-based MRI
contrast agent. Since Magnelles were derived from
magnetotactic bacteria, they have the ability to
self-replicate, making them interesting candidates for
labeling and longitudinal evaluation of cells. This is
crucial for applications such as evaluation of stem cell
and other cell-based therapies. We characterized the MRI
relaxivity properties (both r1 and r2) of Magnelles,
their cell loading and ex vivo imaging characteristics
using a model breast cancer cell line. Magnelles were
found to have similar r2 relaxivity values to
conventional SPIO agents and demonstrated strong MR
contrast for implanted cells.
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