Abstract #0207
Analysis and Optimization of Quantitative Magnetization Transfer Imaging Considering the Effect of Non-Exchanging Component
Pouria Mossahebi 1 , Andrew L Alexander 2,3 , Aaron S Field 1,4 , and Alexey A Samsonov 4
1
Biomedical Engineering, University of
Wisconsin, Madison, WI, United States,
2
Medical
Physics, University of Wisconsin, Madison, WI, United
States,
3
Waisman Lab for Brain Imaging and
Behavior, University of Wisconsin, Madison, WI, United
States,
4
Radiology,
University of Wisconsin, Madison, WI, United States
Gray matter demyelination has recently been recognized
as an important pathological substrate of MS disease. MT
imaging approaches has demonstrated high sensitivity to
myelination in white matter. Its applications to
cortical GM characterization, however, we have to take
into account additional factors related to anatomical
organization of cortical GM such as partial volume
effect (PVE) with CSF. We have proposed a qMT imaging
(NE-mCRI) approach that allows isolating a
non-exchanging (NE) voxel compartment with distinct
relaxation properties such as CSF. In this work, we
analyze the effect of NE component on MTR and mCRI
parameters and provide results of numerical, phantom and
in-vivo validation of the approach as a way to minimize
underestimation of qMT measures due to PVE.
Additionally, we developed a fast-optimized protocol for
in-vivo application of NE-mCRI.
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