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Abstract #0231

Longitudinal comparison of the default mode deactivations in adolescents prenatally exposed to cocaine

Zhihao Li 1 , Priya Santhanam 1 , Claire Coles 2 , Mary Ellen Lynch 2 , Stephan Hamann 3 , and Xiaoping Hu 1

1 Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, Georgia, United States, 2 Psychiatry and Behavioral Science, Emory University, Atlanta, Georgia, United States, 3 Psychology, Emory University, Atlanta, Georgia, United States

The present fMRI study examined the developmental effect of prenatal cocaine exposure (PCE) on default mode network (DMN) deactivations in longitudinally followed adolescents. Comparing age 17 to 15 while performing the same memory task, DMN deactivation was reduced in the control group but increased in the adolescents with PCE. The present results provide direct evidence supporting the view of a long-term effect of PCE on arousal regulation.

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