Abstract #0231
Longitudinal comparison of the default mode deactivations in adolescents prenatally exposed to cocaine
Zhihao Li 1 , Priya Santhanam 1 , Claire Coles 2 , Mary Ellen Lynch 2 , Stephan Hamann 3 , and Xiaoping Hu 1
1
Biomedical Engineering, Emory University &
Georgia Institute of Technology, Atlanta, Georgia,
United States,
2
Psychiatry
and Behavioral Science, Emory University, Atlanta,
Georgia, United States,
3
Psychology,
Emory University, Atlanta, Georgia, United States
The present fMRI study examined the developmental effect
of prenatal cocaine exposure (PCE) on default mode
network (DMN) deactivations in longitudinally followed
adolescents. Comparing age 17 to 15 while performing the
same memory task, DMN deactivation was reduced in the
control group but increased in the adolescents with PCE.
The present results provide direct evidence supporting
the view of a long-term effect of PCE on arousal
regulation.
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