SNR and CNR Comparison of Single-Echo Dixon and Subtraction Contrast-Enhanced MR Angiography

Single-echo Dixon-based methods can provide the benefits (improved SNR, subtraction error reduction) of Dixon-based contrast-enhanced MR angiography (CE-MRA) without extending scan time. A theoretical SNR and CNR analysis of single-echo Dixon compared to subtraction CE-MRA was performed and compared to phantom and in vivo results. Single-echo Dixon CE-MRA provides a contrast concentration-dependent SNR and CNR boost of at least 2 over subtraction CE-MRA. At high contrast concentrations (>3-4mmol) Gadolinium-induced susceptibility artifacts can reduce the SNR and CNR of pre-calibrated Dixon CE-MRA. This technique may allow time-resolved CE-MRA with higher SNR and CNR and improved resistance to motion than subtraction-based methods.

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