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Abstract #0284

Application of compressed-sensing-accelerated diffusion spectrum imaging in patients with brain tumors

Ek T Tan 1 , Robert J Young 2 , Kyung K Peck 2,3 , Xiaofeng Liu 1 , Jonathan I Sperl 4 , Mehrnaz Jenabi 2 , and Luca Marinelli 1

1 GE Global Research, Niskayuna, NY, United States, 2 Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3 Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 4 GE Global Research, Garching, Munich, Germany

Compressed-sensing accelerated diffusion spectrum imaging (CS-DSI) was compared to conventional DTI in ten patients with intracranial brain tumors, whereby DSI clearly provides improved performance in the presence of crossing-fibers and (edema and tumors). DSI acquisition was accelerated by factors of 4 and 5 to achieve scan times under 14 minutes on a conventional 3T system. CS-DSI provided superior tract visualization in all patients. The tract-based dependent measures obtained with CS-DSI were more consistent with pathology-induced changes than those with DTI. These preliminary results suggest that CS-DSI may be helpful in preoperative planning in patients with brain tumors.

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