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Abstract #0300

Assessment of Human Articular Cartilage Using Novel Quantitative MRI Relaxation Parameters with Correlation to Histology and Biomechanical Properties

Jari Rautiainen 1,2 , Elli-Noora Salo 3 , Virpi Tiitu 4 , Mikko A.J. Finnil 5 , Olli-Matti Aho 6 , Simo Saarakkala 3,5 , Petri Lehenkari 6 , Jutta Ellermann 7 , Mikko J. Nissi 7,8 , and Miika T. Nieminen 2,3

1 Department of Applied Physics, University of Eastern Finland, Kuopio, Eastern Finland, Finland, 2 Department of Diagnostic Radiology, University of Oulu, Oulu, Northern Finland, Finland, 3 Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Northern Finland, Finland, 4 Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Eastern Finland, Finland, 5 Department of Medical Technology, University of Oulu, Oulu, Northern Finland, Finland, 6 Department of Anatomy and Cell Biology, University of Oulu, Oulu, Northern Finland, Finland, 7 Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 8 Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, United States

The purpose of this study was to evaluate sensitivity of quantitative MRI techniques for assessment of human tibial articular cartilage with varying degrees of degeneration. For reference, biomechanical measurements, quantitative histology and OARSI grading were performed. The MRI techniques were able to differentiate early osteoarthritis and advanced osteoarthritis specimens and the measures were highly correlated with the biomechanical parameters as well as OARSI grade. Rotating frame MRI techniques (adiabatic T1ρ, adiabatic T2ρ, CW-T1ρ and RAFF) were the most sensitive methods to detect cartilage degeneration.

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