Abstract #0305
pH Dependence of gagCEST at 7T
Ravi Prakash Reddy Nanga 1 , Anup Singh 1 , Hari Hariharan 1 , and Ravinder Reddy 1
1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
Since gag-CEST is promising at 7T for imaging knee
cartilage, we have evaluated the pH sensitivity of
gagCEST on 5% chondrotin sulfate phantoms with varying
pH from 4-8 at both room temperature as well as at 37 C
as there are emerging reports of a pH drop in the knee
cartilage of osteoarthritis subjects.
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