Abstract #0337
An Improved Gradient Echo Myelin Water Imaging using a Frequency Offset Model and Early Echoes
Yoonho Nam 1 , Jongho Lee 2 , Dosik Hwang 1 , and Dong-Hyun Kim 1
1
Department of Electrical and Electronic
Engineering, Yonsei University, Seoul, Korea,
2
Department
of Radiology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States
Myelin water imaging has been proposed as a potential
biomarker for demyelinating diseases. In this study, we
demonstrated that the multi-component model with
frequency offsets offers substantially reliable MWF
results that are less affected by the number of echoes
used in the analysis. Additionally, we revealed that the
MWF map generated from early echoes is less sensitive to
B0 field inhomogeneity and, hence, provides wider brain
coverage. Lastly, we performed a test-retest scan and
demonstrated that the frequency offset model with early
echoes provides more reproducible results.
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