T 1 Measurement of the Myelin Water Fraction

To investigate the possibility of using T ₁ contrast to selectively image myelin water, inversion-recovery prepared multi-gradient-echo imaging was performed on human subjects at 7T. Multi-component fitting of the T ₂ * decay curve allowed distinguishing between water inside and outside the myelin sheath and quantifying individual T ₁ -decay time constants. When properly accounting for imperfect inversion efficiency, no substantial difference between apparent T ₁ of the different compartments was found, suggesting a relatively rapid exchange of water within and outside the myelin sheath.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.