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Abstract #0344

T 1 Measurement of the Myelin Water Fraction

Peter van Gelderen 1 , Xu Jiang 1 , Jacco A de Zwart 1 , and Jeff H Duyn 1

1 AMRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

To investigate the possibility of using T 1 contrast to selectively image myelin water, inversion-recovery prepared multi-gradient-echo imaging was performed on human subjects at 7T. Multi-component fitting of the T 2 * decay curve allowed distinguishing between water inside and outside the myelin sheath and quantifying individual T 1 -decay time constants. When properly accounting for imperfect inversion efficiency, no substantial difference between apparent T 1 of the different compartments was found, suggesting a relatively rapid exchange of water within and outside the myelin sheath.

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