Abstract #0357
Reduced cortical connectivity in excised rat brain with thyroid hormone deficiency
Luis Manuel Colon-Perez 1 , Eric Montie 2 , Michelle Couret 3 , and Thomas Mareci 1
1
Biochemistry and Molecular Biology,
University of Florida, Gainesville, FL, United States,
2
Natural
Science, University of South Carolina Beaufort,
Bluffton, SC, United States,
3
University
of Florida, FL, United States
Thyroid hormone (TH) deficiencies have been shown to
affect the developmental process of myelination in rat
brains. Thyroid hormone deficiencies induce various
neurological symptoms, as cognitive deficits, sensory
and motor impairments. The neurological symptoms related
to TH deficiencies are also associated with changes in
brain structure, which result from the reduction of
white matter volume. Thyroid-hormone deficiency leads to
a decrease in the strength of connectivity measures and
changes in network connectivity. In order to study the
effects of thyroid disruption in rat cortical networks,
we acquired diffusion-weighted data, performed
tractography on ex vivo rat brains and graph theory
analysis
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