Meeting Banner
Abstract #0357

Reduced cortical connectivity in excised rat brain with thyroid hormone deficiency

Luis Manuel Colon-Perez 1 , Eric Montie 2 , Michelle Couret 3 , and Thomas Mareci 1

1 Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States, 2 Natural Science, University of South Carolina Beaufort, Bluffton, SC, United States, 3 University of Florida, FL, United States

Thyroid hormone (TH) deficiencies have been shown to affect the developmental process of myelination in rat brains. Thyroid hormone deficiencies induce various neurological symptoms, as cognitive deficits, sensory and motor impairments. The neurological symptoms related to TH deficiencies are also associated with changes in brain structure, which result from the reduction of white matter volume. Thyroid-hormone deficiency leads to a decrease in the strength of connectivity measures and changes in network connectivity. In order to study the effects of thyroid disruption in rat cortical networks, we acquired diffusion-weighted data, performed tractography on ex vivo rat brains and graph theory analysis

This abstract and the presentation materials are available to members only; a login is required.

Join Here