Abstract #0360
Mapping the presurgical neuroanatomical correlates of postoperative outcome in temporal lobe epilepsy
Simon Sean Keller 1 , Mark Richardson 2 , Jan-Christoph Schoene-Bake 3 , Jonathan OMuircheartaigh 4 , Christian Elger 3 , and Bernd Weber 3
1
Molecular and Clinical Pharmacology,
Institute of Translational Medicine, University of
Liverpool, Liverpool, Merseyside, United Kingdom,
2
Clinical
Neuroscience, Institute of Psychiatry, King's College
London, London, United Kingdom,
3
Department
of Epileptology, University of Bonn, Bonn, Germany,
4
Neuroimaging,
Institute of Psychiatry, King's College London, London,
United Kingdom
We have applied multiple automated mapping methods to
T1-weighted MRIs to determine the presurgical
neuroanatomical correlates of persistent postoperative
seizures (PPS) in patients with medically intractable
temporal lobe epilepsy (TLE). We report that patients
with PPS have atrophy of the mesial temporal lobe
contralateral to the side of intended surgery and of the
thalamus and striatum bilaterally relative to patients
surgically rendered seizure free. The identification of
preoperative bihemispheric hippocampo-thalamo-striatal
abnormalities may indicate susceptibility to PPS in
patients with intractable TLE.
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