Accuracy of Tissue Heterogeneity Corrected MRI-based Treatment Planning in Brain Radiation Therapy
Dilini S. Pinnaduwage 1 , Morgan Yee 1 , Martina Descovich 1 , Josephine Chen 1 , Atchar Sudhyadhom 1 , Ken-Pin Hwang 2,3 , Andras Osztroluczki 4 , and Jean Pouliot 1
Department of Radiation Oncology, University
of California San Francisco, San Francisco, CA, United
MR Applications and Workflow, GE Healthcare, Houston,
TX, United States,
of Imaging Physics, The University of Texas M.D.
Anderson Cancer Center, Houston, TX, United States,
Workstation Applications, GE Healthcare, Szeged, Hungary
MRI is a necessity for tumor delineation in radiation
therapy planning for most cases because it allows the
visualization of soft tissue differences. However, the
current radiation therapy process uses CT for dose
calculation in treatment planning because CT image
intensities, unlike MR image intensities show a clear
relationship with tissue electron densities, allowing
for dose calculation. Thus, MR-CT co-registration is
used to transfer the target contours from MRI to CT. The
purpose of our work is to determine the accuracy of
MRI-based dose calculations by using an automated method
to generate a pseudo CT from an input MRI.
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