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Abstract #0375

Assessment of the pancreatic shear stiffness in healthy volunteers with MR Elastography

Yu Shi 1,2 , Kevin J. Glaser 1 , Jun Chen 1 , and Richard L. Ehman 1

1 Mayo Clinic, Rochester, MN, United States, 2 Department of radiology, Shengjing hospital, Shenyang, Liaoning, China

This study showed that pancreatic MRE using 3D-EPI MRE is feasible in healthy volunteers at low frequencies (40Hz and 60Hz). The shear stiffness for each individual subject and each pancreatic part was consistent among the subjects (approximately 1.0-1.5 kPa at 40 Hz and 1.5-2.5 kPa at 60 Hz). Using 40-Hz vibrations might be more suitable for pancreatic MRE than 60-Hz motion based on the lower CV and higher ICC for inter-rater agreements. For obese subjects, the waves are less likely to penetrate at 60 Hz, causing noise biases and false stiffness estimates.

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