Abstract #0382
Dynamic fPET/fMRI of the human visual system
Marjorie Villien 1 , Joseph B. Mandeville 1 , Hsiao-Ying Wey 1 , Ciprian Catana 1 , Jonathan R. Polimeni 1 , Christin Y. Sander 2 , Nicole R. Zrcher 1 , Daniel B. Chonde 1 , Joanna S. Fowler 3 , Bruce R. Rosen 1 , and Jacob M. Hooker 1
1
Martinos Center for Biomedical Imaging, MGH/Harvard
Medical School, Boston, MA, United States,
2
2Department
of Electrical Engineering and Computer Science, MIT,
Boston, MA, United States,
3
Biosciences
Department, Brookhaven National Laboratory, Upton, NY,
United States
Brain mapping of task-associated changes in metabolism
with PET has been accomplished in the past by
subtracting scans acquired during two distinct static
states. Here we show that PET can provide truly dynamic
information on cerebral metabolism using concepts common
to fMRI. Using 2-[18F]-fluoro-deoxyglucose (FDG), we
show that quantitative glucose utilization changes
during multiple visual stimuli can be determined using
FDG constant infusion in a single-imaging experiment.
This functional PET (fPET-FDG) method can be
accomplished simultaneously with fMRI (BOLD and ASL) and
thus enables the first direct comparisons in time, space
and magnitude of glucose utilization, hemodynamics and
oxygen consumption.
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