Abstract #0384
Correlations between PET and Resting State fMRI of Default Network using Simultaneous PET/MR: Preliminary Results
Yu-Shin Ding 1,2 , Adriana Di Martino 3 , Bangbin Chen 4 , Krishna Somandepalli 3 , Christopher Glielmi 5 , Kritika Nayar 3 , and Francisco X Castellanos 3,6
1
Radiology, New York University School of
Medicine, New York, NY, United States,
2
Psychiatry,
New York University School of Medicine, New York, NY,
United States,
3
Child
and Adolescent Psychiatry, New York University School of
Medicine, NY, United States,
4
National
Taiwan University Hospital, Taiwan,
5
Siemens
Healthcare, NY, United States,
6
Neuroscience
and Physiology, New York University School of Medicine,
NY, United States
Our results demonstrated the feasibility of correlating
FDG metabolism and resting-state fMRI data acquired
simultaneously via a combined PET/MR on healthy
participants. We showed that PCC-based intrinsic
functional connectivity with the anterior node of the
default network is positively related to glucose
consumption, which in turn is related to fluctuations in
the BOLD signal specific to gray matter regions. The
fMRI signals are indirect measures of neuronal activity;
thus, the ability to simultaneously interrogate
metabolism and fMRI indices of brain function in the
same temporal and spatial frames of reference provides
greater insights into whole brain network organization.
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