Meeting Banner
Abstract #0396

Effects of realistic vascular networks anisotropy on MR microvascular imaging

Nicolas Adrien Pannetier 1,2 , Thomas Christen 3 , and Norbert Schuff 1,2

1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2 Centre for Imaging of Neurodegenerative Diseases, VA Medical Center, San Francisco, CA, United States, 3 Department of Radiology, Stanford University, CA, United States

MRI microvasculature imaging is a powerful tool for characterizing hemodynamic properties in vivo. However, the structural complexity of the vasculature may introduce inaccuracy in the estimation of the microvasculature. Using full brain vasculature network acquired with optical microscopy and simulation of the MR signal, we characterized the impact of vascular network anisotropy on the estimation of cerebral blood volume (CBV) and vessel size index (VSI). We found an intrinsic orientation dependent variability of about 20% for CBV and VSI. This works indicates that variations in the spatial distributions of vascular networks need to be considered in microvascular MRI for accurate estimations of hemodynamic properties.

This abstract and the presentation materials are available to members only; a login is required.

Join Here