Abstract #0423
Estimating the influence of magnetization transfer effects on cerebral blood flow quantification in pseudo-continuous arterial spin labeling
Jan Petr 1 , Georg Schramm 1 , Frank Hofheinz 1 , Jens Maus 1 , and Jrg van den Hoff 1
1
PET center, Institute of Radiopharmaceutical
Cancer Research, Helmholtz-Zentrum Dresden Rossendorf,
Dresden, Germany
The magnetization transfer (MT) effects were studied in
pseudo-continuous ASL (pCASL). The MT exchange rate was
obtained from two pCASL sequences with and without
labeling acquired at multiple delays. A mean
white-matter MT exchange rate was obtained and the
exchange rate in blood was derived from it. Effect on
CBF quantification was then calculated using the
standard pCASL quantification model for different
distances from the labeling plane and different blood
velocities in the arteries. CBF underestimation of up to
6% was shown in the slices closest to the labeling plane
if the MT effects were ignored.
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