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Abstract #0426

Bolus-tracking ASL using 3D center-out EPI trajectories in steady-state

Manoj Shrestha 1 , Toralf Mildner 1 , Torsten Schlumm 1 , Kathrin Lorenz 1 , Scott Haile Robertson 2 , and Harald E. Mller 1

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States

Trajectories of cylindrically-encoded 3D center-out EPI readout were used to track an ASL bolus of well-defined length. This was achieved by time-resolved acquisition of single segments of k-space for a period of about 3 s after bolus termination. The steady state created in the imaging volume by the repeated slab selective excitation was maintained also during the ASL bolus. All segments of k-space belonging to the same time after ASL bolus termination were combined and reconstructed. The time-resolved difference images between the labeling and control conditions clearly show the passage of the ASL bolus inside the large brain-feeding arteries.

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