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Abstract #0459

Shorter term aerobic exercise improves brain perfusion, cognition, and cardiovascular fitness in aging

Sina Aslan 1,2 , Sandra Chapman 2 , Jeffrey Spence 2 , Laura DeFina 3 , Nyaz Didehbani 2 , and Hanzhang Lu 4

1 Advance MRI, LLC, Frisco, Texas, United States, 2 Center for BrainHealth, University of Texas at Dallas, Dallas, Texas, United States, 3 The Cooper Institute, Dallas, Texas, United States, 4 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States

This study adds new insights into the mounting evidence of benefits from aerobic training revealing benefits across cardiovascular fitness, cognition, and regional CBF in adults. Most studies show the gains were achieved after six months of physical training. However, the present study shows gains across three domains earlier than previously documented in sedentary middle-aged to old adults. Using pCASL MRI, we measured significant CBF gains in the anterior cingulate region which has been linked to superior cognitive-agers in late life. The findings suggest that healthy life style changes in exercise habits can help to mitigate unnecessary losses.

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