Generation of Multicolor/multiparametric MRI-CEST maps of murine tumor by using YbHPDO3A and Dy-loaded Red Blood Cells.

Three key hallmarks of the tumor development are represented by the increased vascular volume, the enhanced vascular permeability and the acidification of the extracellular/extravascular pH (pHe). CEST contrast agents appear well suitable to visualize simultaneously the three biomarkers by using the currently available 1H-MRI scanners. YbHPDO3A, a small hydrophilic, well tolerated paraCEST agent, chemical analogue of the clinically approved ProHance, provides the way to get information both on change in pHe and on change in vascular permeability. Semi-quantitative information on the vascular volume have been obtained by using Dysprosium- loaded Red Blood Cells, a new kind of CEST contrast agent.

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