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Abstract #0489

Functional connectivity of the primary olfactory cortex is decreased in Alzheimers disease and mild cognitive impairment

Megha M Vasavada 1 , Han Zhang 2 , Jianli Wang 1 , Prasanna Karunanayaka 1 , Paul Eslinger 3 , David Gill 4 , Bing Zhang 5 , and Qing X Yang 1

1 Radiology, Pennsylvania State College of Medicine, Hershey, PA, United States, 2 Hangzhou Normal University, Hangzhou, Zhejiang, China, 3 Neurology, Pennsylvania State College of Medicine, PA, United States, 4 Unity Rehabilitation and Neurology at Ridgeway, NY, United States, 5 Radiology, Nanjing university medical school, Nanjing, China

Olfactory deficits are known to occur in patients with mild cognitive impairment (MCI) and early Alzheimers disease. In this work, we performed olfactory functional magnetic resonance imaging of the primary olfactory cortex and demonstrated that the primary olfactory cortex is involved functionally in early Alzheimers disease.

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