Abstract #0499
Thoracic Aorta 3D Wall Shear Stress as a Marker of Bicuspid Aortic Valve Disease in Pediatric Patients
Bradley D Allen 1 , Pim van Ooij 1 , Alex J. Barker 1 , Maria Carr 1 , Maya Gabbour 2 , Michael Markl 1,3 , Cynthia K Rigsby 2 , and Joshua D Robinson 4
1
Department of Radiology, Northwestern
University, Chicago, IL, United States,
2
Department
of Medical Imaging, Ann & Robert H. Lurie Children's
Hospital of Chicago, Chicago, IL, United States,
3
Department
of Biomedical Engineering, Northwestern University,
Chicago, IL, United States,
4
Division
of Pediatric Cardiology, Ann & Robert H. Lurie
Children's Hospital of Chicago, Chicago, IL, United
States
Pediatric bicuspid aortic valve (BAV) patients are not
at increased risk of cardiovascular complications during
childhood, but often require surgical management of
their disease to limit progressive ascending aorta (AAo)
dilation and reduce their risk of events in adulthood.
Wall shear stress (WSS) has been shown to lead to
vascular remodeling and may be the hemodynamic driver of
progressive AAo dilation in these patient. In this
study, 4D flow MRI was used to non-invasively quantify
3D WSS in the aorta of pediatric BAV patients, and WSS
was found to correlate with AAo diameter and peak
velocity.
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