Abstract #0501
Quantitative assessment of splenic hemodynamics at 4D flow MRI in the evaluation of thrombocytopenia: A pilot study in cirrhotic patients with portal hypertension
Jad Bou Ayache 1 , Zoran Stankovic 1 , Edouard Semaan 1 , James C Carr 1 , Michael Markl 1 , and Jeremy D Collins 1
1
Radiology Department, Feinberg School of
Medicine, Chicago, Illinois, United States
Hypersplenism is a well-recognized, treatable cause of
thrombocytopenia. However, the underlying flow
disturbances contributing to platelet sequestration by
the spleen are unknown. Liver donation, hematologic
malignancy and liver cirrhosis predisposes to
splenomegaly associated with various degrees of
thrombocytopenia. We hypothesized that differences in
splenic hemodynamics could explain the increased
filtration effect independent of splenic size. 4D flow
MRI was performed in patients with liver disease and
healthy volunteers, correlating indexed splenic arterial
and venous flow with platelet counts. Our feasibility
study demonstrates significant differences in indexed
splenic hemodynamics between patients with and without
thrombocytopenia.
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