MRI Measures of Cortical Bone Water Concentration: Dependence on Age and Pore Volume Fraction
Alan C. Seifert 1 , Cheng Li 1 , Hamidreza Saligheh Rad 1 , Chamith S. Rajapakse 1 , Wenli Sun 1 , Shing Chun Benny Lam 1 , and Felix W. Wehrli 1
Radiology, University of
Pennsylvania, Philadelphia, PA, United States
Increased cortical porosity is a major cause of
impaired strength of osteoporotic bone.
Ultrashort echo-time MRI can detect short-T2
components in cortical bone and enables
measurement of bulk bone water content (BWC).
The suppression ratio (SR, ratio of signal
without and with long-T2 suppression) may better
reflect bone porosity. BWC is quantified in 72
humans and SR in 40 humans and 13 bone
specimens, and these measurements are compared
to x-ray-based modalities. Although SR is not an
absolute measurement of pore volume fraction, SR
is more highly correlated with age and porosity
than pQCT mineral density or BWC.
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