Simultaneous fat, water and T2* mapping of trabecular bone and comparison with high resolution MRI in the hip
Pippa Storey 1 , Gregory Chang 1 , Stephen Honig 2 , Kashif Khokhar 1 , Mary T. Bruno 1 , David R. Stoffel 1 , and Sandra L. Moore 1
Radiology Department, New York
University School of Medicine, New York, NY,
of Rheumatology, New York University School of
Medicine, New York, NY, United States
Destruction of trabecular bone can result from
osteoporosis or malignant processes, and is
difficult to characterize adequately using
conventional methodologies. We compared
simultaneous fat, water and T2* mapping with
high resolution trabecular imaging in the hips
of 30 patients with osteoporosis or osteopenia.
T2* is known to be sensitive to trabecular
density since the magnetic susceptibility of
mineralized bone differs from that of marrow. In
addition, fat content may potentially allow
discrimination of osteoporosis from malignant
infiltration. Elevated T2* was found to be
correlated with trabecular paucity, both in
terms of anatomic distribution and across
patients (Spearman r=0.64, p=0.00014).
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