In vivo T 2 * effect on pharmacokinetic parameter estimation using reference tissue arterial input function at 7T

The influence of T ₂ ^* on lesion signal intensity and arterial input function at high field can induce systemic errors in pharmacokinetic parameter estimation. When the arterial input function is estimated from reference tissue, the T ₂ ^* effect on parameter estimation may be relatively smaller than when it is directly measured. In this study, we investigate the influence of a Gd-based contrast agent on the T ₂ ^* of tumor at 7T and its effect on kinetic model analysis. Our preliminary results show no significant difference between pharmacokinetic model parameters from T ₂ ^* -corrected and non-corrected data when a reference tissue arterial input function is used.

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