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Abstract #0524

In vivo T 2 * effect on pharmacokinetic parameter estimation using reference tissue arterial input function at 7T

Jin Zhang 1 , Melanie Freed 1 , Kerryanne Winters 1 , and Sungheon Kim 1

1 Radiology, New York University, New York, New York, United States

The influence of T 2 * on lesion signal intensity and arterial input function at high field can induce systemic errors in pharmacokinetic parameter estimation. When the arterial input function is estimated from reference tissue, the T 2 * effect on parameter estimation may be relatively smaller than when it is directly measured. In this study, we investigate the influence of a Gd-based contrast agent on the T 2 * of tumor at 7T and its effect on kinetic model analysis. Our preliminary results show no significant difference between pharmacokinetic model parameters from T 2 * -corrected and non-corrected data when a reference tissue arterial input function is used.

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