Abstract #0530
Vascular Fingerprinting in Rat Brain Tumors
Benjamin Lemasson 1,2 , Nicolas Pannetier 3,4 , Rgine Farion 1,2 , Emmanuel Barbier 1,2 , Norbert Schuff 3,4 , Michael Moseley 5 , Greg Zaharchuk 5 , and Thomas Christen 5
1
U836, Iserm, Grenoble, France,
2
Grenoble
Institut des Neurosciences, Universit Joseph Fourier,
Grenoble, France,
3
Va
medical center, Centre for neurodegenerative des eases,
San Francisco, CA, United States,
4
University
of California San Francisco, Department of Radiology and
Biomedical Imaging, San Francisco, CA, United States,
5
Stanford
University, Department of Radiology, Stanford, CA,
United States
In this study, we tested the vascular fingerprinting
approach in 8 rats bearing brain tumors. This recent
method compares
in
vivo
MR
signal time evolutions to a dictionary of curves
obtained with numerical simulations and creates maps of
microvascular characteristics. We obtained good
correlations with more conventional MR methods:
steady-state susceptibility contrast imaging for blood
volume mapping, Vessel Size Imaging and multiparametric
quantitative BOLD imaging for blood oxygen saturation
measurements. In two rats, high spatial resolution maps
were obtained and compared to pimonidazole staining, a
histological marker of tissue hypoxia.
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