Abstract #0554
ASSESSING MYELOMA BONE DISEASE WITH WHOLE BODY DIFFUSION WEIGHTED IMAGING (WB-DWI): COMPARISON WITH X-RAY SKELETAL SURVEY (SS) AND LABORATORY ESTIMATES OF DISEASE BURDEN
Sharon L Giles 1 , Nandita M DeSouza 2 , David J Collins 2 , Veronica A Morgan 1 , Sharon West 3 , Faith E Davies 3 , Gareth J Morgan 3 , and Christina Messiou 4
1
Clinical Magnetic Resonance Unit, Royal
Marsden Hospital, Sutton, Surrey, United Kingdom,
2
Clinical
Magnetic Resonance Unit, Institute of Cancer Research,
Sutton, Surrey, United Kingdom,
3
Haemato-oncology
Department, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom,
4
Department
of Radiology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom
WB-DWI offers an alternative to SS for detection of
myeloma bone disease. This prospective study compared
extent of disease shown by WB-DWI and SS by body region
(measured by image scores) and correlated the imaging
burden of disease (measured by scores and ADC metrics)
with the pathological assessment of disease (measured by
serum paraprotein and bone marrow histology). WB-DWI
scores were significantly higher than SS scores per
patient and in every body region except the skull. WB-DWI
scores were higher in those with a high disease burden,
but there were no significant correlations between
imaging and pathological measures of disease.
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