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Abstract #0556

Measuring human glomerular morphology and pathology with MRI

Scott C. Beeman 1 , Luise Cullen-McEwan 2 , Min Zhang 3 , Teresa Wu 3 , Edwin J. Baldelomar 4 , John P. Dowling 2 , Jennifer R. Charlton 5 , Michael S. Forbes 5 , Amanda Ng 2 , Qi-zhu Wu 2 , James A. Armitage 2 , Victor G. Puelles 2 , Gary F. Egan 2 , John F. Bertram 2 , and Kevin M. Bennett 4

1 Washington University in St Louis, St Louis, Missouri, United States, 2 Monash University, Victoria, Australia, 3 Arizona State University, Arizona, United States, 4 University of Hawaii at Manoa, Hawaii, United States, 5 University of Virginia, Virginia, United States

Nephron number and size are correlated with risk for chronic cardiovascular and kidney disease and may predict renal allograft viability. Unfortunately, there are no techniques to assess total glomerular number and volume in intact human kidneys. This work demonstrates the use of cationized ferritin as a glomerulus-specific MRI contrast agent to measure glomerular number, volume, and spatial distribution and to detect arterial and glomerular damage in human kidneys.

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