Abstract #0558
On Contrast-Enhanced MR Imaging in the Presence of Pathological Plasma-Protein Concentrations
Daniel Nanz 1 , Stefan Gtschi 2 , Johannes M Froehlich 3,4 , Natalie Chuck 2 , Raffaele Curcio 5 , Val Murray Runge 2 , Gustav Andreisek 2 , and Andreas Boss 2
1
Institute for Diagnostic and Interventional
Radiology, University Hospital Zrich, Zrich, Zrich,
Switzerland,
2
Institute
for Diagnostic and Interventional Radiology, University
Hospital Zrich, Zrich, Switzerland,
3
Institute
of Pharmaceutical Sciences, Swiss Federal Institute of
Technology, ETHZ, Zrich, Switzerland,
4
Guerbet
AG, Zrich, Switzerland,
5
Institute
of Clinical Chemistry, University Hospital Zrich,
Zrich, Switzerland
In an in-vitro study with dilution series of
commercially available gadolinium-based MR imaging
contrast agents, human-serum albumin and human-serum
immunoglobulin G, and based on a multi-variate
protein-specific evaluation of the experimental
relaxivity data, it could be shown that pathological
deviations from normal blood-serum concentration levels
of both proteins strongly alter the signal enhancement
induced by gadolinium-based MR contrast agents, which
may have implications for a wide range of (quantitative)
gadolinium-based contrast-enhanced MR imaging
applications.
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