Abstract #0567
Pontine Hyperintensities are a Sensitive Indicator of Small Vessel Disease in Elderly Patients with Dementia
Owen Thomas 1 , Ammar Issa 2 , Thomas P Hansen 2 , John Cain 2 , Nitin Purandare 3 , and Alan Jackson 2
1
Department of Neuroradiology, Salford Royal
NHS Hospitals Foundation Trust, Manchester, Lancashire,
United Kingdom,
2
Wolfson
Molecular Imaging Centre, University of Manchester,
Manchester, Lancashire, United Kingdom,
3
Greater
Manchester Old Age Psychiatry Service, University of
Manchester, Manchester, Lancashire, United Kingdom
We examine the discriminative power of brainstem
hyperintensities in an elderly population of patients
with vascular dementia (VaD), Alzheimers dementia (AD)
and age-matched normal controls. Hyperintensities in the
pons were scored using a novel system and combined with
scores of hyperintensity in the hemispheric
white-matter, dilated perivascular spaces, lacunar and
hemispheric infarcts. The presence of pontine and medial
lemniscus hyperintensities provided the greatest
independent discriminative power for the separation of
VaD and AD accounting for 40% and 12% of the variance in
the linear regression model respectively. The area under
the receiver operator curve was 0.833.
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